AstraZeneca: Enabling New Medicines Through Semantic Knowledge Graphs

This is an abbreviated and updated version of a presentation from Graphwise Graph AI Summit 2025 by Ben Gardner, R&D lead for Data Mesh and Semantic Infrastructure at AstraZeneca   Our understanding of disease evolves constantly, and with it, our ability to treat patients effectively. A century ago, cancer was considered a single disease. Then we refined our understanding of cancers of specific organs – cancer of the lung, for instance. Later, we distinguished between different cell types, like non-small cell lung cancer. Today, we examine individual mutational profiles of cancers and.